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KMID : 0363320190400030443
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Journal of Korean Oriental Internal Medicine
2019 Volume.40 No. 3 p.443 ~ p.457
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Clinical Research Trends in Respiratory Diseases Related to Particulate Matter
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Lyu Yee-Ran
Kim Jin-Hoo
Yang Won-Kyung
Kim Seung-Hyung
Park Yang-Chun
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Abstract
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Objectives: This study aimed to review the clinical research trends in respiratory diseases related to particulate matter (PM) to help design clinical studies on herbal medicine that protects against PM.
Methods: We searched three international databases (Pubmed, EMBASE, and CENTRAL) to investigate clinical studies on respiratory diseases related to PM and to analyze their study design, respiratory-related disease, inclusion/exclusion criteria, study period, outcome measure, study results, measurement method and range of PM.
Results: A total of 18 studies were finally selected, including 13 observational studies and 5 randomized controlled trials. The selected studies showed an increasing trend from 1985 to 2018 and were conducted mostly in North America, followed by Europe and Asia. Subject disease and age were decided in variety by each study objective, although asthma accounted for the majority. For the outcome assessment, pulmonary function test was mostly used for lung function. Quality of life questionnaires and biomarkers in blood and sputum were also used.
Conclusion: A well-designed clinical study on herbal medicine that protects against PM is needed, and this study is expected to be used as base data.
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KEYWORD
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particulate matter, respiratory disease, clinical studies, herbal medicine
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